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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name E6/E7 siRNA
ncRNA Category siRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines OCM1, OM431, VUP and SP6.5
Methods PCR, DNA CHIP, Western blot, siRNA transfection, MTT assay, flow cytometry
Expression pattern associated
Functional description Down regulation of HPV 18E6/E7 led to growth inhibition and cell cycle block in VUP cells by activation of the p53 and Rb pathways.
PubMed ID 23494180
Year 2013
Title Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA.
Drug-related ncRNA NO

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